Endocannabinoids 101

What is the Endocannabinoid System?


Cannabinoids are the chemical compounds secreted by cannabis flowers that provide relief to an array of symptoms. Cannabinoids work by imitating compounds our bodies naturally produce, called endocannabinoid, which activate to maintain internal stability and health.

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WHY DOES THIS MATTER? (ENTOURAGE EFFECT)

HUMAN ENDOCANNABINOID SYSTEM 

The most well-known cannabinoid receptors, CB1 and CB2, are proteins that are embedded in the membrane of cells.  These surface proteins are then attached to another protein that determines the signaling direction activation or inhibition

CB1 

CB1 Receptors are primarily found in the brain and central nervous system, and to a lesser extent in the other tissues. 

CBl Receptors target: 

  • Appetite 

  • Immune cells 

  • Motor activity 

  • Motor coordination 

  • Pain perception 

  • Short term memory 

  • Thinking 

CB2 

CB2 Receptors are mostly in the peripheral organs especially cells associated with the immune system. 

CB2 Receptors target: 

  • Adipose tissue 

  • Bone 

  • Cardiovascular system 

  • Central nervous system 

  • Eyes

  • Gut

  • Immune system 

  • Kidneys 

  • Liver 

  • Pancreas

  • Reproductive system 

  • Respiratory tract 

  • Skeletal muscle 

  • Skin

  • Tumors 

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